Pros: It is a sewn binding, so you can actually open it and it stays open. Excellent book introductions (see the excellent 10 page intro to Revelation, for example), many pages of supplemental helps in the back, good footnotes, practical helps, maps and charts in the text (like the different interpretations of various schools in Daniel's visions, to name one of many), the history of salvation in the OT book by book outline has been helpful to me. The historical material is excellent. The notes are very "reformed friendly" but not as "Reformed" as the SOTR or RSB.
Cons: I am picking at nits, here. It has many timelines scattered throughout the text, but not "one comprehensive" timeline in an easy to find location. The concordance is a bit skimpy for a giant book. If you get one in a font big enough to read, it will weigh 7 pounds (seriously, its huge). I have the one with 10 point type
Assuming that you don't mind "study bibles," the ESV Study has raised the bar and is the gold standard of study bibles right now, In my humble opinion.