1643 - John Campanius, Lutheran missionary to the Indians, arrives in America on the Delaware River; Reformed pastor Johannes Megapolensis begins outreach to American Indians while pastoring at Albany
1644 - John Eliot begins ministry to Algonquin Indians in North America
1649 - Society for the Propagation of the Gospel In New England formed to reach the Indians of New England -- John Eliot was named its first missionary
1701 - John Jackson, the first missionary to Newfoundland to be supported by the Society for the Propagation of the Gospel, arrives at St. John's.
1702 - George Keith, Scotch Quaker, arrives in America as a missionary of the newly-organized Society for the Propagation of the Gospel in Foreign Parts.
1703 - The Society for the Propagation of the Gospel in Foreign Parts expands its work to the West Indies
1709 - Experience Mayhew, missionary to the Martha's Vineyard Indians, translates the Psalms and the Gospel of John into the Massachusett language. It will be a work considered second only to John Eliot's Indian Bible in terms of significant Indian-language translations in colonial New England.
1723 - Solomon Stoddard, Jonathan's Edwards' grandfather, chastises New Englanders for their neglect of Indian souls in a sermon titled: "Whether God Is Not Angry with the Country for Doing So Little toward the Conversion of the Indians?" Stoddard felt that colonial wars and other trials were God's punishment for neglecting the colony's commitment as spelled out in the 1629 Massachusetts Bay charter to bring the gospel to the Indians.
1735 - John Wesley goes to Indians in Georgia as missionary with the Society for the Propagation of the Gospel
1739 - The first missionary to the Mahican (Mohegan) Indians, John Sergeant, builds a home in Stockbridge, Massachusetts that is today a museum.
1740 - Moravian David Zeisberger starts work among Creek Indians of Georgia
1745 - One day in late December, David Brainerd, missionary to Native American Indians, writes in his journal: "After public worship was over, I went to my house, proposing to preach again after a short season of intermission. But they soon came in one after another; with tears in their eyes, to know, what they should do to be saved. . . . It was an amazing season of power among them, and seemed as if God had bowed the heavens and come down ... and that God was about to convert the whole world."
1746 - From Boston, a call is issued to the Christians of the New World to enter into a seven-year "Concert of Prayer" for missionary work
1747 - Jonathan Edwards appeals for prayer for world missions
1750 - Jonathan Edwards, preacher of the First Great Awakening, having been banished from his church in Massachusetts, goes as a missionary to the nearby Housatonic Indians; Christian Frederic Schwartz goes to India with Danish-Halle Mission
1751 - Samuel Cooke arrives in New Jersey as a missionary for the Society for the Propagation of the Gospel in Foreign Parts
1754 - Moravian John Ettwein arrives in America from Germany in as a missionary. Preaching to Native American tribes and establishing missions, he will travel as far south as Georgia. Eventually Ettwein will become bishop and head of the Moravian church in the United States.
1755 - The Mahican Indian settlement at Gnadenhutten, Pa. is attacked and destroyed. Moravian missionary Johann Jacob Schmick who pastors a group of Indian converts will remain with the Mahicans through exile and captivity, though facing almost constant threats from white neighbors. Schmick will join his Indian congregation as they seek refuge in Bethlehem, follow them as captives to Philadelphia, and remain with them after they settle in Wyalusing (also called Friedenshutten), Pennsylvania.
1759 - Native American Samson Occom, direct descendant of the great Mohegan chief Uncas, is ordained by the Presbyterians. Despite poor eyesight, Occom became the first American Indian to publish works in English. These included sermons, hymns and a short autobiography.
1763 - The Presbyterian Synod of New York orders that a collection for missions be taken. In 1767 the Synod will ask that this collection be done annually.
1780 - August Gottlieb Spangenberg writes An Account of the Manner in Which the Protestant Church of the Unitas Fratrum, or United Brethren, Preach the Gospel, and Carry On Their Missions Among the Heathen. Originally written in German, the book will be translated into English in 1788.
1781 - In the midst of the American Revolutionary War, the British so feared Moravian missionary David Zeisberger and his influence among the Delaware and other Native American Indians that they arrested him and his assistant, John Heckewelder, charging them with treason,
1784 - Methodist Thomas Coke submits his Plan for the Society for the Establishment of Missions Among the Heathen. Methodist missions among the 'heathen' will begin in 1786 when Coke, destined for Nova Scotia, is driven off course by a storm and lands at Antigua in the British West Indies.
1798 - The Missionary Society of Connecticut is organized by the Presbyterians. Its missionaries worked within the U.S., evangelizing both European settlers and Native Americans.